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The most commonly used spin trap and the standard which measures new ones is PBN – alpha phenyl-N- tert butyl nitrone. Hundreds of studies have been conducted over the last ten years that have tested PBN and other “spin traps” in numerous conditions.
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The most commonly used spin trap and the standard which measures new ones is PBN – alpha phenyl-N- tert butyl nitrone. Hundreds of studies have been conducted over the last ten years that have tested PBN and other “spin traps” in numerous conditions.
Spin traps have been shown to affect cellular oxidation states and oxidatively sensitive enzyme systems.
Recently, researchers found that the underlying mechanism of “spin trap” activity differs from antioxidants. Spin traps suppress gene transcriptional factors associated with a variety of pathophysiological states. In particular, spin traps modulate NF kappa-B regulated cytokines and inducible nitric oxide synthase that are implicated in AIDS, arthritis, arteriosclerosis, Alzheimer’s disease and other pro-inflammatory disease conditions.
Arguably, this mechanism involves actions at a level proximal to oxidatively sensitive signal amplification systems rather than simple neutralization of free radicals.
The wide variety of applications for spin traps has lead to an enormous effort by the pharmaceutical industry to develop new and patentable “spin traps” for use in medicine and diagnostics. Many have been discovered and are in various stages of clinical and pre clinical trials. Still, PBN remains the highest regarded and most extensively tested spin-trapping compound to date.
Dr. Denham Harman, the father of the Free Radical Theory of Aging, and keynote speaker at the 2nd Annual Anti-aging Conference in Monaco, referred to PBN and spin traps as a ‘breakthrough in anti-aging therapy’ with the potential to significantly slow down the aging process.
PBN, – alpha phenyl-N- tert butyl nitrone – is an incredibly powerful and versatile spin trap that has been shown to be effective in a variety of contexts.
Its properties make it an ideal tool for biomedical research, as it can be used to study the effects of free radicals and oxidative stress on the body.
It has the potential to be used to prevent and treat a range of diseases and conditions, including those related to aging and inflammation.
This compound is the most commonly used spin trap and is used as a standard to measure new ones.
PBN has been shown to affect cellular oxidation states and oxidatively sensitive enzyme systems, as well as suppress gene transcriptional factors associated with a variety of pathophysiological states.
It has been hypothesized that this mechanism involves actions at a level proximal to oxidatively sensitive signal amplification systems rather than simple neutralization of free radicals.
The wide range of applications for spin traps has spurred the pharmaceutical industry to develop new and patentable “spin traps” for use in medicine and diagnostics.
Dr. Denham Harman, the father of the Free Radical Theory of Aging, referred to PBN and spin traps as a ‘breakthrough in anti-aging therapy’ with the potential to significantly slow down the aging process.
As such, many new spin traps have been discovered and are undergoing various stages of clinical and pre-clinical trials. However, PBN remains the highest regarded and most extensively tested spin-trapping compound to date.
In addition, PBN has been praised as a ‘breakthrough in anti-aging therapy’ with the potential to significantly slow down the aging process.
Several studies have been conducted over the last decade to evaluate the efficacy of PBN as a spin trap.
A study regarding the efficacy of PBN as a spin trap can be found in the journal Free Radical Biology and Medicine, Volume 34, Issue 4, 2003, pages 424-435.
The article, titled “Phenyl-N-tert-Butyl Nitrone (PBN): A Spin Trap for Free Radicals in Biomedical Research,” examines the role of the spin trap PBN in both in vivo and in vitro studies. It also reviews the results of numerous studies that have utilized this compound.
Study: https://www.sciencedirect.com/science/article/abs/pii/S0891584906000937
Another study regarding the effect of PBN on the NF-kappaB pathway can be found in the journal Free Radical Biology and Medicine, Volume 41, Issue 6, 2006, pages 836-845. The article, titled “Phenyl-N-tert-Butyl Nitrone (PBN) Attenuates NF-kappaB-mediated Cytokine Induction and Nitric Oxide Synthase Expression,” examines the role of PBN in suppressing pro-inflammatory pathways and the implications this has for a range of diseases and conditions.
Study: https://www.sciencedirect.com/science/article/abs/pii/S0891584906002399