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GeroNova’s Bio-Enhanced® R-Lipoic Acid in the form of Na RALA has demonstrated superior bio-availability, stability and potency.
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The primary benefit of the completely water-soluble salt is that high blood and tissue levels can be achieved rapidly. Bio-Enhanced® R-Lipoic Acid may deliver all the health benefits of lipoic acid; antioxidant protection and efficient energy production and may result in an increased sense of well-being and improved health-span for regular consumers.*
Our proprietary stabilization process converts the biologically active, natural “R” form of lipoic acid to sodium-R-lipoic acid (Na RALA), which, in a recent human study achieved 40 times higher peak blood levels than pure R-lipoic acid.
| Weight | 3.53 oz |
|---|---|
| Dimensions | 4.45 × 2.44 × 2.4 in |
R-Lipoic Acid (from 300 mg Sodium R-Lipoic Acid)* 255 mg
Other Ingredients: vegetable cellulose (capsule), rice flour (non-GMO)
Does Not Contain: Wheat, Gluten, Corn, Yeast, Soy, Egg, Dairy Products, Artificial Colors, Artificial Sweeteners, or Artificial Flavors.
This product uses GeroNova Research’s Bio-Enhanced® R-Lipoic Acid. Bio-Enhanced is a registered trademark of GeroNova Research, Inc.
Take 1 or more capsules daily or as recommended by a health-care practitioner.
Allergy Warning: This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.
Pregnancy Warning: If pregnant, consult your health-care practitioner before using this product.
Interactions: There are no known adverse interactions or contraindications at publication date.
Note Regarding Sodium: R-Lipoic acid in the form of the sodium salt (Na-RALA) contains 8-9% sodium. However, one serving of this product contains less than 1% of the Daily Value for sodium, an insignificant contribution to dietary sources. Research suggests that sodium may impact blood pressure in some individuals only when it is consumed as sodium chloride (NaCl, table salt) and not in other forms. The sodium in this product is unlikely to affect blood pressure levels.
Lipoic acid, also known as Alpha-Lipoic acid, (ALA, Thioctic acid) is similar in structure and function to a vitamin. ALA has been widely explored as a beneficial nutrient for a variety of bodily functions involving the nervous, cardiovascular, immune and detoxification systems.*
Alpha-Lipoic acid consists of a 50/50 mixture of the R-(natural) and S-(unnatural) enantiomers that are mirror images of each other and is called a ‘racemic’ mixture. It is the most widely available commercial form of alpha lipoic acid.
While it may come as a surprise, the vast majority of Alpha-Lipoic acid products on the market also contain the unnatural S form of Lipoic acid that is not found anywhere in nature and did not even exist until it was chemically synthesized in 1952. There is evidence that the two enantiomers of Alpha-Lipoic acid have different biological activities.
Much of the research over the past 30 years has been done with racemic Alpha-Lipoic acid because the R form was not commercially available. This was due to its instability and tendency to polymerize once isolated from the S form, and due to the challenges of delivering the R form to the body in bio-available dosage forms compared to racemic Alpha-Lipoic acid.
S-Lipoic Acid (The S (-) enantiomer) is not found in nature. S-Lipoic acid (SLA) is a by-product from chemical synthesis of racemic Alpha-Lipoic acid and may inhibit the most essential properties of the R form, including interactions with proteins, enzymes and genes.
R-Lipoic Acid (the R (+) enantiomer) is the form of lipoic acid that occurs naturally in plants, animals and the human body and is responsible for the specific beneficial effects of Alpha-Lipoic acid. R-lipoic acid (RLA) is the only form that functions as a co-factor for mitochondrial enzymes involved in energy production.
R-Lipoic acid, despite all its potential health benefits, when separated from the S form, is physically unstable. R-Lipoic acid deteriorates relatively rapidly at slightly above room temperature into a sticky insoluble polymer. Moisture and the heat of friction during encapsulation and the compression of tablets are sufficient to initiate this process. Even a partially polymerized product can pose significant problems in the manufacturing and stability of a dosage form. The polymer reduces the dissolution of tablets or capsules, reduces GI absorption and lowers the bio-availability to less than 10%.
Numerous factors affect absorption. Racemic-ALA has poor solubility and absorption from the GI tract, as 20- 30% reaches the plasma vs. an intravenous dose. R-Lipoic acid is even less soluble and polymerizes on contact with the low pH environment of the stomach. Without special processing, R-Lipoic acid is highly unstable and difficult to absorb.
The good news is that GeroNova has developed a way to stabilize R-Lipoic acid and make it much more bio-available – this means more of it is absorbed. In fact, a human trial found that people who took Bio-Enhanced® R-Lipoic Acid achieved blood concentrations of Lipoic acid a full 40 times higher than those who took unstabilized RLA.**
Maximum Absorption in nanograms/mL
GeroNova’s R-lipoic acid supplements:
1 Bio-Enhanced® R-Lipoic Acid capsule = 40 Unstabilized R-Lipoic Acid capsules
Although small amounts of R-lipoic acid are available in food sources such as dark leafy greens, broccoli, beef, and organ meats, supplementation may be needed to achieve significant intake levels.¹²
Scientific studies showing the health benefits of lipoic acid have used doses ranging from 300 mg to 1,800 mg per day. Lipoic acid has generally been found to be safe when administered in recommended doses. Among the rare reported side effects in humans have been skin allergies and gastrointestinal distress.
As lipoic acid may lower blood glucose levels, individuals with diabetes or glucose intolerance should have their blood glucose monitored while taking lipoic acid. They should also consult their physician about adjusting their dose of anti-diabetic medication in order to avoid hypoglycemia¹.
Since the long-term use of lipoic acid has not yet been studied in pregnant women and nursing mothers, these individuals should avoid using lipoic acid until more information is available¹.
