A recent study conducted by Cristina Esposito et al. has investigated the safety and efficacy of alpha lipoic acid oral supplementation in the reduction of pain with unknown etiology. This double-blind, placebo controlled, clinical trial was conducted to evaluate the efficacy and safety of LA supplementation compared to placebo in reducing pain in subjects with unknown etiology. The results of the study show that LA supplementation is effective in reducing pain, with no significant side effects. The subjects of the study were randomly assigned to either the LA group or the placebo group, and the primary outcome measure was the change in pain intensity from baseline to the end of the study. After 12 weeks of treatment, the LA group had a significantly lower pain intensity compared to the placebo group, indicating that LA supplementation is effective in reducing pain.

Furthermore, the LA group had a significantly lower use of rescue medication compared to the placebo group, indicating that LA supplementation is effective in reducing the need for rescue medication.

Overall, the study showed that ALA supplementation is safe and effective in reducing pain of unknown etiology, to be researched as a potential solution.

There have also been other studies investigating the efficacy of LA in the management of pain. For example, a study published in the journal Pain Research and Management found that LA supplementation was associated with a significant decrease in pain severity and disability in patients with chronic low back pain. Another study published in the journal Phytotherapy Research found that LA supplementation was associated with a significant reduction in pain intensity in patients with fibromyalgia.

While more research is needed to further investigate the safety and efficacy of LA supplementation for pain relief, the results of this study are encouraging and could lead to new treatments for pain management.

https://pubmed.ncbi.nlm.nih.gov/34649217/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6840741/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014529/