Acetyl L-Carnitine and L-Carnitine Orotate
Mind, Memory & Energy Support: GeroNova’s CARNITINE-PLUS formula provides two stable and highly beneficial forms of Carnitine: Acetyl L-Carnitine (ALCAR) and L-Carnitine Orotate.
- A combination of Acetyl-L-Carnitine and L-Carnitine Orotate may complement the role of R-Lipoic acid in the production of cellular energy, and potentially supports cognitive function while serving an antioxidant role in the brain and peripheral nervous system.*
Carnitine, derived from an amino acid, is found in nearly all cells of the body. Carnitine plays a critical role in energy production. It transports long-chain fatty acids into the mitochondria so they can be oxidized (“burned”) to produce energy. It also transports the toxic compounds generated out of this cellular organelle to prevent their accumulation. Given these key functions, carnitine is concentrated in tissues like skeletal and cardiac muscle that utilize fatty acids as a dietary fuel.
Carnitine has been studied extensively because it is important to energy production and is a well-tolerated and generally safe therapeutic agent. Researchers prefer to use Acetyl-L-carnitine in research studies because it is better absorbed from the small intestine than L-carnitine and more efficiently crosses the blood-brain barrier.
Benefits of L-Carnitine Orotate
- L-Carnitine Orotate is a salt of L-Carnitine and Orotic Acid and is superior to other forms of Carnitine, because both parts of the compound — the Carnitine and the Orotic Acid — are active.
Orotic acid (also known as vitamin B13) may be useful in:
- Promoting the reproduction of liver cells and normalizing liver enzyme systems.*
- Metabolization of folic acid and vitamin B12.*
- Assisting in the absorption calcium and magnesium.*
- Assisting the absorption of essential nutrients.*
- Supporting the production of genetic material.*
L-Carnitine Orotate is more absorbable than regular L-Carnitine.
By combining these two forms of Carnitine into one product, CARNITINE-PLUS provides effective natural support for your mind, your memory and your body.*
Combine Carnitine and R Lipoic Acid
For best results, combine a Carnitine product with an R-Lipoic Acid (RLA) product. R-Lipoic acid and Carnitine complement one another in the production of energy.* In fact, animal research indicates that the combination of R-Lipoic acid and Carnitine may be more beneficial than either product taken alone.
A decline in mitochondrial function is thought to contribute to the aging process. Carnitine may be involved because its concentration in tissues declines with age and thereby reduces the integrity of the mitochondrial membrane. Research in aged rats found supplementation with Acetyl-L-carnitine and R-lipoic acid to reduce mitochondrial decay. The animals also moved about more and improved their performance on memory-requiring tasks. At present there are no equivalent studies of this kind in humans. However, a meta-analysis of double-blind, placebo-controlled studies suggests that supplements of Acetyl-L-carnitine may improve mental function and reduce deterioration in older adults with mild cognitive impairment and Alzheimer’s disease. In these studies, subjects took 1.5–3.0 grams/day of Acetyl-L-carnitine for 3–12 months.
* This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Acetyl-L-Carnitine 500 mg, L-Carnitine 250 mg (from 420 mg Carnitine Orotate) – 120 vegcaps/bottle
Cellulose (capsule), silicon dioxide.
Take 2 or more capsules per day between meals or as directed by your health care provider. Can also be taken 30 minutes before excercise.
Statements and Warnings
This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.
It’s best not take Carnitine-PLUS in the evening, as it may interfere with sleep.
This product does not contain wheat, gluten, corn, yeast, soy, egg, dairy products, artificial colors, artificial sweeteners, or artificial flavors.
If pregnant, consult your healthcare practitioner before using this product.
There are no known adverse interactions or contraindications at publication date.
At doses of approximately 3 g/day, carnitine supplements can cause nausea, vomiting, abdominal cramps, diarrhea, and a “fishy” body odor. Rarer side effects include muscle weakness in uremic patients and seizures in those with seizure disorders.
Carnitine is considered a “conditionally essential” nutrient. That means that while the human body can normally make Carnitine, there are some circumstances where it does not make enough. During those times, Carnitine has to be supplied through the diet (mostly in red meats and dairy products) or through taking supplements.
Clinical Carnitine deficiency is rare. However, diabetics, pregnant and nursing women, vegetarians and athletes may have lower than optimal levels.