The Use of R-ALA in Patients with Mild-Moderate Carpal Tunnel Syndrome

April 21, 2020 Consumer Blog By



Carpal tunnel syndrome is one of the most common peripheral neuropathies. Only a few studies evaluate the efficacy of “nutraceuticals” on peripheral nerves and neuropathic pain. The aim of the present investigation is to evaluate the role of R-ALA on clinical and functional outcomes in patients affected by mild to moderate carpal tunnel syndrome.

Material and Methods:

The present investigation is a prospective randomised controlled open label study, performed at our Hand Surgery Department (Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome) from October 2018 to March 2019. The enrolled patients were divided in two groups: Group A (R-ALA 600mg once day for 60 days) and Group B (control Group, no drug administration).


134 patients (74 F, 60 M) met the inclusion and exclusion criteria. In Group A, there was a statistically significant pain reduction compared to the control Group. Using the Boston Carpal Tunnel Questionnaire, there were no significant improvements in the other symptoms and function.


R-ALA full dose administration for two months leads to positive short term results in terms of symptoms and function improvement, even if the surgical carpal tunnel release remains the treatment of choice.


  1. Passiatore M, Perna A, De-Vitis R, Taccardo G.
  2. Malays Orthop J. 2020 Mar;14(1):1-6. doi: 10.5704/MOJ.2003.001.

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