Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer’s Disease?

August 20, 2020 Consumer Blog By

Alpha-Lipoic Acid presents a neuroprotective and anti-inflammatory molecule profile with the ability to revert cellular damage in the central nervous system; thus, it is considered an epigenetic modulator in mechanisms associated with oxidative stress and inflammation. Therefore, α-LA protects against the progression or even the establishment of the toxic tissue environment resulting from the pathogenesis of AD. These characteristics make α-LA a nutraceutical with great potential for the treatment of this disease, as well as an agent with potential benefits for mitochondrial dysfunction. The ability to act on the reestablishment of mitochondrial function could block the progression or even reverse the damage to the brain tissue that occurs in AD.


  1. Oxid Med Cell Longev
  2. 2019 Nov 30;2019:8409329.
  3. doi: 10.1155/2019/8409329. eCollection 2019.
  4. Sávio Monteiro dos Santos, Camila Fernanda Rodrigues Romeiro, Caroline Azulay Rodrigues, Alícia Renata Lima Cerqueira, and Marta Chagas

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