Science Blog

Effect of Curcumin and α-Lipoic Acid in Attenuating Weight Gain and Adiposity.

OBJECTIVE: Obesity is growing at epidemic proportions worldwide. Natural compounds curcumin and α-lipoic acid have been shown to reduce body-weight gain in both preclinical and clinical studies. This study examined the effect of a combination of curcumin and α-lipoic acid on weight gain and adiposity in high-fat-diet (HFD)-fed mice. METHODS: C57BL6 mice (7 weeks old) […]

March 12, 2019 Science Blog By GeroNova Research

Elevated blood pressure reduction after α-lipoic acid supplementation: a meta-analysis of randomized controlled trials.

The aim of the comprehensive meta-analysis was to systematically explore the reductive effect of α-lipoic acid (ALA) supplementation on systolic blood pressure (SBP) and diastolic blood pressure (DBP). The related records were selected from PubMed, Scopus, EMBASE, Cochrane library, and Persian databases including SID and Magiran from earliest date 1980 until August 2018. The heterogeneities […]

March 12, 2019 Science Blog By GeroNova Research

Effect of Alpha-Lipoic Acid Supplementation on Endothelial Function and Cardiovascular Risk Factors in Overweight/Obese Youths: A Double-Blind, Placebo-Controlled Randomized Trial.

Endothelial dysfunction is recognized as an early sign of systemic atherosclerosis, and it represents a therapeutic target to prevent long-term cardiovascular (CV) consequences. Alpha-lipoic acid (ALA) is a commonly used dietary supplement exerting anti-oxidant and anti-inflammatory effects. We investigated whether a three-month treatment with ALA improves endothelial function, as assessed by flow-mediated dilation (FMD) of […]

March 12, 2019 Science Blog By GeroNova Research

Potential Therapeutic Effects of Lipoic Acid on Memory Deficits Related to Aging and Neurodegeneration.

Abstract The aging process comprises a series of organic alterations, affecting multiple systems, including the nervous system. Aging has been considered the main risk factor for the advance of neurodegenerative diseases, many of which are accompanied by cognitive impairment. Aged individuals show cognitive decline, which has been associated with oxidative stress, as well as mitochondrial, […]

February 27, 2018 Consumer Blog By GeroNova Research

Effect of Alpha-Lipoic Acid on Clinical and Neurophysiologic Recovery of Carpal Tunnel Syndrome: A Double-Blind, Randomized Clinical Trial

The objective of our study was to examine the effect of alpha-lipoic acid (ALA) on clinical and neurophysiologic outcomes after surgery for idiopathic carpal tunnel syndrome (CTS). We conducted a randomized, double-blind, placebo-controlled clinical trial in 20 adults diagnosed with idiopathic CTS after clinical and neurophysiologic assessment. Eligible participants took 600 mg ALA or placebo per […]

February 27, 2018 Consumer Blog By GeroNova Research

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