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Effect of an oral supplementation with a formula containing R-lipoic acid in glaucoma patients.

Abstract OBJECTIVE: To analyse the safety and effectiveness of the oral administration of a commercialised supplement containing R-alpha lipoic acid, taurine, vitamins C and E, lutein, zeaxanthin, zinc, copper and docosahexaenoic acid, in patients with primary open angle glaucoma (POAG), and in control subjects. MATERIAL AND METHODS: A prospective study of cases and controls was […]

March 11, 2020 Consumer Blog By GeroNova Research

HMGB1 is increased in adolescents with polycystic ovary syndrome (PCOS) and decreases after treatment with myo-inositol (MYO) in combination with alpha-lipoic acid (ALA).

Abstract PCOS treatment should be based on pathophysiology. High-mobility-group-box-1 (HMGB1) was shown to increase in PCOS patients as a consequence of reduced cystic-fibrosis-transmembrane-conductance-regulator (CFTR) expression in the ovary, and was associated with insulin resistance and inflammation, both features of PCOS. Inositols and ALA derivatives could have positive effects on insulin sensitivity, reduce androgens, and improve […]

March 11, 2020 Science Blog By GeroNova Research

Alpha-lipoic acid inhibits lung cancer growth via mTOR-mediated autophagy inhibition.

Abstract Lung cancer is the leading cause of cancer-related death, and there remains a need for novel therapies for this malignancy. Here, we examined the effects of alpha-lipoic acid (LA), a drug used for treating human diabetic complications, on lung cancer growth. We report that LA limited lung cancer growth in xenograft mice and reduced […]

March 11, 2020 Consumer Blog By GeroNova Research

Alpha-Lipoic acid supplementation significantly reduces the risk of obesity in placebo controlled clinical trials.

Abstract BACKGROUND: There are numerous trials reported the effect of ALA on obesity measurements; while no summarized dose-response meta-analysis is available to address the effects of dose and duration of ALA supplementation on obesity measurements. We aimed to summarize the results of studies evaluating the effects of ALA supplementation on obesity measurements in a systematic […]

March 11, 2020 Consumer Blog By GeroNova Research

Alpha-Lipoic Acid Inhibits Proliferation and Invasion of Human Gastric Cancer Cells

Background: Metastasis and invasion are the main causes of mortality in gastric cancer. To improve the treatment of gastric cancer, the development of effective and innovative antitumor agents toward invasion and proliferation is needed. Alpha-lipoic acid (ALA), a naturally occurring thiol antioxidant, showed antiproliferative and cytotoxic effects on several cancers. So it is feasible to […]

January 15, 2020 Science Blog By GeroNova Research

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