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The osteogenesis-promoting effects of lipoic acid against glucocorticoid-induced osteoporosis

Recently, accumulating evidence has indicated that glucocorticoid-induced osteoporosis (GIOP) is closely related to oxidative stress and apoptosis. Glucocorticoid medications have both direct and indirect effects on bone tissue that lead to bone loss. These drugs have a direct negative effect on bone cells, resulting in a reduced rate of forming new bone. Also, they can […]

June 16, 2017 Consumer Blog By GeroNova Research

Lipoic Acid Decreases the Viability of Breast Cancer Cells

International Institute of Anticancer Research (Dr. George J. Delinasios). Protein tyrosine phosphatases PTP1B and SHP2 are potential targets for anticancer therapy, because of the essential role they play in the development of tumors. PTP1B and SHP2 are overexpressed in breast cancer cells, thus inhibition of their activity can be potentially effective in breast cancer therapy. […]

May 28, 2017 Consumer Blog By GeroNova Research

The effect of lipoic acid on chronic sciatic pain: clinical data from 44 Italian centers

OBJECTIVE: To provide information on the clinical presentation of sciatic neuropathy and its management in a real-world setting, and to analyze the effects of a multimodal approach based on the association of physical and pharmacological therapy. PATIENTS AND METHODS: A multicentric observational prospective study was conducted in 44 Italian tertiary centers specialized in Physical Medicine […]

April 23, 2017 Consumer Blog By GeroNova Research

Researchers Identify Metabolic Mechanism for R-Lipoic Acid-Induced Cell Death in Liver Cancer Cells

A new study that measured metabolite levels over time in starved rat liver cancer cells showed that treatment with R-Lipoic acid (RLA) inhibited glucose uptake and glycolysis, and led to decreased cellular glucose production from non-carbohydrate sources, which may help explain how the naturally occurring R form of LA promotes the death of hepatoma cells. […]

April 11, 2017 Consumer Blog By GeroNova Research

Alpha-lipoic acid prevents kidney stone formation in experimental model

A communication published online on February 6, 2017 in Nature Medicine found a role for alpha-lipoic acid in the prevention of kidney stones in a mouse model of cystinuria: an inherited disease that results in recurrent kidney stone formation. In a collaboration between the University of California, San Francisco (UCSF) and the Buck Institute, Tiffany Zee, PhD, and colleagues […]

February 19, 2017 Consumer Blog By GeroNova Research

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