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Alpha lipoic acid inhibits oxidative stress-induced apoptosis by modulating of Nrf2 signalling pathway after traumatic brain injury.

Alpha lipoic acid (ALA) is a powerful antioxidant which has been widely used in the treatment of different system diseases, such as cardiovascular and cerebrovascular diseases. But, there are few studies that refer to protective effects and potential mechanisms on traumatic brain injury (TBI). This study was carried out to investigate the neuroprotective effect following […]

May 30, 2019 Science Blog By GeroNova Research

The Immunomodulatory Effect of Alpha-Lipoic Acid in Autoimmune Diseases.

Αlpha-lipoic acid is a naturally occurring antioxidant in human body and has been widely used as an antioxidant clinically. Accumulating evidences suggested that α-lipoic acid might have immunomodulatory effects on both adaptive and innate immune systems. This review focuses on the evidences and potential targets involved in the immunomodulatory effects of α-lipoic acid. It highlights […]

May 30, 2019 Science Blog By GeroNova Research

Lipoic Acid as Therapy for Multiple Sclerosis.

Oxidative stress (OS), when oxidative forces outweigh endogenous and nutritional antioxidant defenses, contributes to the pathophysiology of multiple sclerosis (MS). Evidence of OS is found during acute relapses, in active inflammatory lesions, and in chronic, longstanding plaques. OS results in both ongoing inflammation and neurodegeneration. Antioxidant therapies are a rational strategy for people with MS […]

May 30, 2019 Science Blog By GeroNova Research

MEMORY AND BRAIN AMYLOID AND TAU EFFECTS OF CURCUMIN IN NON-DEMENTED ADULTS: A DOUBLE-BLIND, PLACEBO-CONTROLLED 18-MONTH TRIAL

Background Because the anti-inflammatory and anti-amyloid properties of curcumin could protect the brain from age-related neurodegeneration and memory decline, we studied the effects of curcumin on memory performance in non-demented adults and explored its potential impact on brain amyloid plaques and tau tangles using FDDNP-PET. Methods Forty subjects (age 51 to 84 years) were randomized […]

April 23, 2019 Science Blog By GeroNova Research

Curcumin May Reverse Memory Problems, Improve Mood

With more and more of the aging population affected by Alzheimer’s disease, and clinical trials for new medications often providing underwhelming results, a new study in The American Journal of Geriatric Psychiatry may be especially promising. It finds that taking a daily dose of curcumin, the compound in turmeric root that gives curry its yellow […]

April 23, 2019 Science Blog By GeroNova Research

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