Research Overview

GeroNova Research is setting the industry standards for research, analysis and lipoic acid products.

GeroNova Publications

Interaction of α-Lipoic Acid with the Human Na+/Multivitamin Transporter (hSMVT).

J Biol Chem. 2015 Jun 26;290(26):16372-82. doi: 10.1074/jbc.M114.622555. Epub 2015 May 13.
Zehnpfennig B1, Wiriyasermkul P2, Carlson DA3, Quick M4.

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Author Affiliations:
  1. From the Center for Molecular Recognition and
  2. Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032.
  3. GeroNova Research, Inc.
  4. From the Center for Molecular Recognition and Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York 10032.

Evaluation of the Role of Chirality and Amide Substitution in Redox Modulation of Signal Transduction by Lipoic Acid and Derivatives.

Poster Presentation, Oxygen Club of California, Alba, Italy June 20-23, 2012. Carlson DA.(1) He DY.(1) Kalashnikova E.(1) Gendelman R.(1, 2) Fischer SJ.(1), Packer L.(3)

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Author Affiliations:
  1. GeroNova Research Inc.
  2. University of California San Francisco Cancer Center, San Francisco, CA 94115
  3. Pharmacy and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90089

Therapeutic Potential of Lipoamide and Enhanced Mitochondrial Biogenesis for Treatment of Insulin Resistance

Shen W, Carlson DA, Packer L, Cadenas E, Liu J. Chapter 5 in Mitochondrial Signaling in Health and  Disease (93-111) Eds. Orrenius S, Cadenas E and Packer L. CRC Press, Taylor & Francis Group, Boca Raton, London, New York (2012)
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Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer’s disease

Maczurek A (b,c), Hager K (a), Kenlies M (a), Sharman M (d), Martins R (a), Engel J (e), Carlson DA (f), Münch G (b,c). Advanced Drug Delivery Reviews (2008)

Read the abstract on the Pub Med website

Author Affiliations

a. Klinik für Medizinische Rehabilitation und Geriatrie der Henriettenstiftung,
Hannover, Germany
b. Dept. of Pharmacology, School of Medicine, University of Western Sydney,
c. Dept. of Biochemistry and Molecular Biology, James Cook University,
d. Centre of Excellence for Alzheimer’s Disease Research and Care, Edith Cowan
University, Australia
e. Zentaris GmbH, Frankfurt am Main, Germany
f. GeroNova Research, Inc., USA

An Evaluation of the Stability and Pharmacokinetics of R-lipoic Acid and R-Dihydrolipoic Acid Dosage Forms in Plasma from Healthy Human Subjects

Carlson DA, Young KL, Fischer SJ, Ulrich H. Chapter 10 in: Packer L, Patel M, eds.Lipoic Acid: Energy Production, Antioxidant Activity and Health Effects. London, England: Taylor & Francis Publishers; 2008:235-270.

The Plasma Pharmacokinetics of R-(+)-Lipoic Acid Administered as Sodium R-(+)-Lipoate to Healthy Human Subjects.

Carlson DA, Smith AR, Fischer SJ, Young KL, Packer L. Altern Med Rev 2007;12(4) 343-351

A comparison of the pharmacokinetic profiles of lipoate enantiomers with the racemic mixture in healthy human subjects indicates possible stereoselective gut transport.

Carlson DA, Smith AR, Fischer SJ, Young KL.

Further characterization of the lipoic acid enantiomers provide new research opportunities. Stereochemistry, Pharmacokinetics & Metabolism:Toward a Comprehensive Mechanism of Action

Oxygen Club of California PowerPoint presentation by David A.Carlson, March,15, 2008.

Lipoic acid in Alzheimer’s disease – From basic therapeutic concepts to clinical trials

Marlies Kenklies, Klaus Hager, Gerald Münch, Shanmugam Kirubakaran, Annette Maczurek, Grant Stuchbury, David Carlson

The case against controlled release lipoic acid: A pharmacokinetic-mechanistic argument (part 1)