Introducing: GeroNova Research, Inc. “The Lipoic Acid Company”

GeroNova is a privately funded dietary supplement company specializing in anything to do with lipoic acid. A pioneer in developing novel Lipoic Acid laboratory-scale synthesis, industrial-scale asymmetric synthesis and production, GeroNova is the only dietary supplement company currently sponsoring academic and clinical research with leading researchers and doctors world-wide to increase the knowledge pool by publication in peer reviewed scientific journals.

GeroNova performs in-house Lipoic Acid related research for publication and new product development. This dedicated focus and emphasis on research has led to alliances with leading scientists, earned the respect of medical practitioners and to the production of the most stable, efficacious and absorbable Lipoic Acid products available anywhere in the world.

Superior Absorption Profiles are obtained by using GeroNova’s R-Lipoic Acid Supplements

Medical doctors, alternative health practitioners and natural products retailers are familiar with the many benefits Lipoic Acid also known as (R/S)-Lipoic Acid, (+/-) Alpha-Lipoic Acid (ALA), rac-LA or RS-LA.

GeroNova’s R-Lipoic Acid Products are:

  • Made with only the naturally occurring, R-Lipoic Acid salts or contain a combination of R-Lipoic Acid and its reduced form, R-Dihydrolipoic Acid (DHLA).
  • Formulated using a unique stabilization process that ensures maximum stability.
  • Designed for superior absorption. In fact, pharmacokinetic data demonstrate Bio-Enhanced® R-Lipoic Acid has 40x the absorption rate of unstabilized RLA.
  • Free of excipients and chemical additives.
  • Shelf-Stable even when exposed to prolonged heat greater than 45 deg C.
  • Designed for superior G.I. absorption.

Pharmacokinetic data demonstrates Bio-Enhanced® R-Lipoic Acid has up to 40x greater absorption than R-Lipoic Acid in the common powder form.

The optimal form of Lipoic Acid

lipoic acid absorptionMost commercial R-Lipoic, aka “R” form is considered the “eutomer” (the biologically superior form) of Alpha Lipoic Acid since it is identical to that produced by the body and has existed as long as life has existed on earth. Research indicates R-Lipoic Acid is responsible for many if not most of the beneficial effects attributed to Lipoic Acid.

Commercial Lipoic Acid Products

Despite the advantages of Lipoic Acid, most commercial Alpha-Lipoic Acid supplements available today are not offered in the optimal form. These less expensive products are a 50/50 mixture of the naturally occurring R-Lipoic and unnatural S-Lipoic. S-Lipoic Acid is a byproduct of achiral chemical synthesis and did not exist prior to 1952. Research indicates S-Lipoic may inhibit the absorption of some of the most essential properties R-Lipoic Acid (see research page).

RS-Lipoic Acid contains 50% unnatural S-Lipoic Acid and suffers lower aqueous solubility; it may lower intestinal absorption compared to the quick acting, highly bio-available salts, Na RALA and K-RALA. R-Lipoic Acid in the common yellow powder form found in commercial capsules readily polymerizes into a sticky insoluble “rubber” when exposed even briefly to high temperatures or moisture. RLA powder pressed into tablets disintegrate poorly and in capsules incompletely dissolves and displays lower overall absorption (see Research page and published studies)

According to Dr. Guido Zimmer; “R- and S- enantiomers of the physiological compound alpha-lipoic acid have been synthesized. The S-enantiomer is not a naturally occurring compound. This part of the racemate, which is present as about a 50% impurity, needs to be eliminated”. (Zimmer et al 1995)
Zimmer G, Mainka L, Ulrich H. ATP synthesis and ATPase activities in heart mitoplasts under influence of R- and S-enantiomers of lipoic acid. Methods Enzymol (1995) 251 332-40.

While R-Lipoic Acid is the obvious choice over Alpha-Lipoic Acid, in its “free-acid” yellow powder form, pure R-Lipoic Acid has two major drawbacks: low shelf stability and low bio-availability. R-Lipoic Acid is significantly more expensive than RS-LA but without special processing is prone to polymerization and is incompletely absorbed. In fact, pharmacokinetic data reveal that while RS-Alpha Lipoic Acid has a lower absorption profile than RLA salts, non-stabilized R-Lipoic Acid powder is absorbed to an even lower extent than racemic-LA. (see the pharmacokinetic data on Research page)

The world’s first stabilized RLA from GeroNova

  • Setting the industry standards for research, analysis and products.
  • Solved the problem of the lack of shelf stability of R-Lipoic Acid.
  • Maximized oral absorption by introducing the world’s first stabilized water soluble and gel-based R-Lipoic Acid.
  • Peer reviewed scientific studies conducted by GeroNova have shown that Bio-Enhanced® R-Lipoic Acid is the most bio-available oral form of Lipoic Acid on the market. A preliminary human trial found that people who consumed GeroNova’s Bio-Enhanced® R-Lipoic Acid achieved blood concentrations of R-Lipoic Acid up to 40 times higher than those who consumed RLA capsules or powder.

    To distribute GeroNova’s product line of R-Lipoic Acid supplements in your practice or retail store, call us today at (775) 887-4907 or email