Bio-Enhanced® Na-Rala


Na RALA is the sodium salt form of R-Lipoic Acid, providing heat stable, low polymer bulk powder and capsules, with fast dissolution rates, high solubility and absorption.

Only R-Lipoic acid of the highest purity is utilized, after independent HPLC enantioselective analysis confirms the R/S ratio. Salts of weak acids (R-Lipoic acid is a weak acid [pKa=4.7]) have a much higher aqueous solubility than the free acid. This being the case, if a material can be taken as a salt (Na RALA) the solubility can be increased and there is improved oral bioavailability.

Bio-Enhanced® Na R-Lipoic acid is much more stable than R-Lipoic acid even at elevated temperatures. Heated to over 150° C for 6 hours there is no loss of activity, and polymer formation was undetectable. Pure R-Lipoic acid would instantaneously polymerize under these conditions.

Bio-Enhanced® Na R-Lipoic acid requires no refrigeration and does not polymerize, whereas R-Lipoic acid polymerizes at temperatures slightly above ambient. The polymerization of R-Lipoic acid is accelerated by light, heat and moisture.

Bio-Enhanced® Na R-Lipoic acid does not cause heartburn, indigestion or stomach discomfort, unlike unstabilized R-Lipoic Acid.

Compare Pure R-Lipoic acid and Bio-Enhanced® Na R-Lipoic acid

GeroNova’s in-house stability, pharmacokinetic, plasma and tissue studies using state-of-the-art analytical equipment reveal that commonly used ‘pure’ (unstabilized) R-Lipoic acid utilized in most commercially available R-Lipoic acid products has very low GI absorption and bio-availability, significantly lower than racemic Alpha Lipoic Acid. See our In-House Research Page.

Unstabilized R-Lipoic acid can also contain harmful heavy metals and residual solvents that are very difficult to remove. The processing and stabilization of Bio-Enhanced® Na R-Lipoic acid removes all traces of residual solvents from the raw material.