Although small amounts of R-lipoic acid are available in food sources, such as dark leafy greens like spinach and collards, broccoli, beef, and organ meats, supplementation may be needed to achieve significant intake levels.1,2
Scientific studies showing the health benefits of lipoic acid have used doses ranging from 300 mg to 1,800 mg per day. Lipoic acid has generally been found to be safe when administered in recommended doses. Among the rare reported side effects in humans have been skin allergies and gastrointestinal distress.
As lipoic acid may lower blood glucose levels, individuals with diabetes or glucose intolerance should have their blood glucose monitored while taking lipoic acid. They should also consult their physician about adjusting their dose of anti-diabetic medication in order to avoid hypoglycemia.1
Since the long-term use of lipoic acid has not yet been studied in pregnant women and nursing mothers, these individuals should avoid using lipoic acid until more information is available.1