R-Lipoic acid is highly unstable and difficult to absorb unless it has been specially processed. GeroNova developed and was first to offer a variety of improved “2nd-Generation” R-Lipoic acid containing products. The stand-alone or combination products selected depend on personal preferences and self-experimentation:
Some consumers prefer the quick absorption and fast action of the GeroNova brand water-soluble salts of R-Lipoic acid while others prefer the slow absorption and longer half-life of the gel-based products. GeroNova scientists and medical advisers currently believe the optimal use may involve both forms in equal amounts from 100 mg up to 600 mg/day due to differences in the pharmacokinetics (For references and technical details, please see the Research Page.)
The benefit of water-soluble salts is that they reach high blood levels and are taken up into the tissues quickly.
R-Lipoic acid in the form of the sodium salt (Na-RALA) contains 8-9% sodium and is formulated using a proprietary stabilization process in order to insure maximum shelf stability and absorption. The primary benefit of the completely water-soluble salt is that high blood and tissue levels can be achieved rapidly. Bio-Enhanced® R-Lipoic Acid may deliver all the benefits of lipoic acid; antioxidant protection and efficient energy production and may result in an increased sense of well-being and improved health-span for regular consumers.*
R-(+)-Lipoic acid in the form of the potassium salt (K-RALA) is pre-dissolved in water. One dropper full contains approximately 100 mg RLA but displays significantly higher blood and tissue levels than 100 mg administered as RLA powder. K-RALA-10® Liquid is rapidly absorbed, fast acting and suitable for children who can take single drops added to water. K-RALA-10® is favored by consumers preferring dietary supplements in liquid form.
R-PLUS Curcumin is a formula containing Bio-Enhanced® R-Lipoic Acid with high bio-availability Bio-Curcumin (as BCM-95). Curcumin may provide antioxidant protection and may provide joint, hepatic, gastrointestinal and cardiovascular support. The results of in vitro and animal models suggests the combination of R-(+)-Lipoic acid and Curcumin supports detoxification and elimination of toxins.*
R-PLUS contains a 50/50 mixture of R-Lipoic acid stabilized with its reduced form R-Dihydrolipoic Acid, also known as R-DHLA in gelcaps. The two forms work closely together in vitro (in cell culture) and in vivo (in the body) by swapping electrons as needed to fight free radicals and generate energy (ATP). The benefit of oil-based R-PLUS is that it has a longer half life, meaning it stays in the body longer. In fact, blood levels of regular users can be measured for several days at low levels after regular consumption and even after discontinued use.
Preliminary pharmacokinetic data from GeroNova indicates consumption of R-Lipoic acid in combination with R-DHLA may result in higher blood levels of R-Lipoic acid in consumers than in those who use R-Lipoic acid in the more commonly available powder form.
The primary benefit of the completely water-soluble salts is rapid achievement of high blood and tissue levels. The unique benefit of R-PLUS is slower intestinal absorption and detection in the blood longer than the fast acting forms. Preliminary studies conducted by GeroNova indicate there may be advantages in consumption of equal amounts of the fast acting water-soluble R-Lipoic acid salts-Bio-Enhanced® R-Lipoic Acid vegcaps & K-RALA-10® Liquid R-Lipoic Acid-in combination with the oil-based R-PLUS softgels. The combination may deliver the benefits of both unique forms. As pharmacokinetic studies progress, GeroNova will update consumers with the latest results and most advanced formulas based on the current science.
Animal research indicates that the combination of R-Lipoic acid and carnitine may be more beneficial than either product taken alone.
A combination of Acetyl-L-Carnitine and L-Carnitine Orotate may complement the role of R-Lipoic acid in the production of cellular energy, and potentially supports cognitive function while serving an antioxidant role in the brain and peripheral nervous system.*
A combination of L-Carnitine with L-Carnitine Orotate, essential support for skeletal and cardiac muscle function by assisting in the conversion of fat to energy, and L-Carnitine Orotate providing liver support.
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