Recently, accumulating evidence has indicated that glucocorticoid-induced osteoporosis (GIOP) is closely related to oxidative stress and apoptosis.
Glucocorticoid medications have both direct and indirect effects on bone tissue that lead to bone loss. These drugs have a direct negative effect on bone cells, resulting in a reduced rate of forming new bone. Also, they can interfere with the body’s handling of calcium and affect levels of sex hormones. Either of these problems can lead to increased bone loss.
Lipoic acid has been implicated as a therapeutic agent for the treatment of GIOP. In a new study, the osteogenesis-promoting effects of LA against GIOP were investigated and the mechanisms were further probed. The results showed that LA inhibited oxidative stress, suppressed apoptosis and improved osteopenia by promoting the expression of osteogenesis markers. The present study indicated that LA may prevent GIOP and promote osteogenesis and might be a candidate for the treatment of GIOP.
Sci Rep. 2017 Jun 13;7(1):3331. doi: 10.1038/s41598-017-03187-w.