Gerald is a biochemist and pharmacologist whose research was initially focused on carbonyl stress (resulting in the formation of Advanced Glycation Endproducts, AGE’s) in age-related diseases such as diabetes, renal failure and Alzheimer’s’ disease (AD). More recently, he has investigated the role of chronic inflammation in AD. He has also elucidated some of the pro-inflammatory signaling pathways of the B-amyloid and AGE-receptor RAGE, as well as the involvement of reactive oxygen species (“redox-signaling”) in this pathway.
His current research projects have identified a variety of antioxidants – including polyphenolic compounds that interfere with inflammation and could be beneficial in the treatment of AD. In collaboration with Prof. K. Hager at the Henriettenstiftung (Hannover, Germany), a clinical trial of such an “anti-inflammatory” antioxidant, alpha-lipoic acid, was initiated. Data collected over a four year period show that in patients in early stages of the disease, the progression rate was 50% slower compared to untreated patients.
Institution Degree Year Subject University of Wurzburg, Germany Dipl. Chem. 1987 Chemistry University of Wurzburg, Germany Ph.D. 1991 Biochemistry University of Wurzburg, Germany 1992 Neurochemistry
Garvan Institute, Sydney 1994 Molecular Neurobiology
1997 Prize for “Brain Research in Gerontology” of the Universitat Witten-Herdecke, Germany 2003 Rene-Schubert-Prize for Experimental Gerontology of the German Society for Aging Research
1995 – 1999: Lecturer Physiological Chemistry I (Biocenter) University of Würzburg, Germany 1999 Senior Lecturer Dept. of Child and Adolescent Psychiatry University of Würzburg, Germany 2000 – 2003 Senior Research Fellow/ A/Prof Neuroimmunological Cell Biology Unit University of Leipzig, Germany 2003-2008: Comparative Genomics Centre, James Cook University, Townsville, Queensland, Australia 2008- Associate Professor, Chair of Pharmacology, School of Medicine, University of Western Sydney, Australia
Journal of Neural Transmission (Springer), Journal of Alzheimer’s Disease (IOS Press), Current Pharmaceutical Design (Bentham)
Maczurek A, Hager K, Kenklies M, Sharman M, Martins R, Engel J, Carlson DA, Munch G. Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer’s disease. Advanced Drug Delivery Reviews, Volume 60, Issues 13-14, October-November 2008, Pages 1463-1470. Mitochondrial Medicine and Mitochondrion-Based Therapeutics
Schonberger T, Siegel-Axel D, Bußl R, Richter S, Judenhofer MS, Haubner R, Reischl G, Klingel K, Munch G, Seizer P, Pichler BJ, Gawaz M.The immunoadhesin glycoprotein VI-Fc regulates arterial remodelling after mechanical injury in ApoE-/- mice. Cardiovasc Res. 2008 Jul 7.
Maczurek A, Shanmugam K, Meunch G.Inflammation and the redox-sensitive AGE-RAGE pathway as a therapeutic target in Alzheimer’s disease. Ann N Y Acad Sci. 2008 Apr;1126:147-51.
Shanmugam K, Holmquist L, Steele M, Stuchbury G, Berbaum K, Schulz O, Benavente García O, Castillo J, Burnell J, Garcia Rivas V, Dobson G, Munch G. Plant-derived polyphenols attenuate lipopolysaccharide-induced nitric oxide and tumour necrosis factor production in murine microglia and macrophages. Mol Nutr Food Res. 2008 Apr;52(4):427-38
Berbaum K, Shanmugam K, Stuchbury G, Wiede F, Korner H, Munch G.Induction of novel cytokines and chemokines by advanced glycation endproducts determined with a cytometric bead array. Cytokine. 2008 Mar;41(3):198-203.
Hager K, Kenklies M, McAfoose J, Engel J, Munch G. Alpha-lipoic acid as a new treatment option for Alzheimer’s disease–a 48 months follow-up analysis. J Neural Transm Suppl. 2007;(72):189-93. Holmquist L, Stuchbury G, Steele M, Munch G.Hydrogen peroxide is a true first messenger. J Neural Transm Suppl. 2007;(72):39-41.
Schmidt A, Kuhla B, Bigl K, Munch G, Arendt T. Cell cycle related signaling in Neuro2a cells proceeds via the receptor for advanced glycation end products. J Neural Transm. 2007;114(11):1413-24.
Muscat S, Pelka J, Hegele J, Weigle B, Munch G, Pischetsrieder M. Coffee and Maillard products activate NF-kappaB in macrophages via H2O2 production. Mol Nutr Food Res. 2007 May;51(5):525-35. Bigl K, Schmitt A, Meiners I, Munch G, Arendt T. Comparison of results of the CellTiter Blue, the tetrazolium (3-[4,5-dimethylthioazol-2-yl]-2,5-diphenyl tetrazolium bromide), and the lactate dehydrogenase assay applied in brain cells after exposure to advanced glycation endproducts. Toxicol In Vitro. 2007 Aug;21(5):962-71.
Kuhla B, Haase C, Flach K, Luth HJ, Arendt T, Munch G. Effect of pseudo-phosphorylation and crosslinking by lipid peroxidation and advanced glycation end product precursors on tau aggregation and filament formation. J Biol Chem. 2007 Mar 9;282(10):6984-91.
Holmquist L, Stuchbury G, Berbaum K, Muscat S, Young S, Hager K, Engel J, Munch G. Lipoic acid as a novel treatment for Alzheimer’s disease and related dementias. Pharmacol Ther. 2007 Jan;113(1):154-64.
Steele M, Stuchbury G, Munch G. The molecular basis of the prevention of Alzheimer’s disease through healthy nutrition. Exp Gerontol. 2007 Jan-Feb;42(1-2):28-36.
Langer AK, Poon HF, Munch G, Lynn BC, Arendt T, Butterfield DA. Identification of AGE-modified proteins in SH-SY5Y and OLN-93 cells. Neurotox Res. 2006 Jun;9(4):255-68.
de Arriba SG, Stuchbury G, Yarin J, Burnell J, Loske C, Munch G. Methylglyoxal impairs glucose metabolism and leads to energy depletion in neuronal cells–protection by carbonyl scavengers. Neurobiol Aging. 2007 Jul;28(7):1044-50.
Bültmann A, Herdeg C, Li Z, Munch G, Baumgartner C, Langer H, Kremmer E, Geisler T, May A, Ungerer M, Gawaz M.Local delivery of soluble platelet collagen receptor glycoprotein VI inhibits thrombus formation in vivo. Thromb Haemost. 2006 May;95(5):763-6.
Reinhardt R, Manaenko A, Guenther A, Franke H, Dickel T, Garcia de Arriba S, Muench G, Schneider D, Wagner A, Illes P. Early biochemical and histological alterations in rat corticoencephalic cell cultures following metabolic damage and treatment with modulators of mitochondrial ATP-sensitive potassium channels. Neurochem Int. 2003 Nov;43(6):563-71.
Dukic-Stefanovic S, Gasic-Milenkovic J, Deuther-Conrad W, Munch G (2003) Pro-inflammatory signal transduction pathways in mouse microglia N-11 cells activated by advanced glycation endproducts. J Neurochem 87: 2609-2615
Munch G, Apelt J, Kientsch-Engel R, Stahl P, Lüth HJ, Schliebs R (2003) Advanced glycation endproducts (AGEs) and pro-inflammatory cytokines in transgenic Tg2576 mice with amyloid plaque pathology. J Neurochem 86: 283-289
Munch G, Gasic-Milenkovic J, Dukic-Stefanovic S, Kuhla B, Heinrich K, Riederer P, Huttunen HJ, Founds H, Sajithlal G(year 2003) Microglial activation induces cell death, inhibits neurite outgrowth and causes neurite retraction in differentiated neuroblastoma cells Exp Brain Res 150: 1-8.
Gasic-Milenkovic J, Dukic-Stefanovic S, Deuther-Conrad W, Gartner U, Munch G (2003) ß-amyloid peptide potentiates inflammatory responses induced by lipopolysaccharide, interferon gamma and “advanced glycation endproducts” in a murine microglia cell line. Eur J Neurosci 17 :813-21
Munch G, Shepherd CE, McCann H, Brooks WS, Kwok JBJ, Arendt T, Hallupp M, Schofield PR, Martins RN, Halliday GM (2002) Intraneuronal advanced glycation endproducts in presenilin-1 Alzheimer’s disease. Neuroreport 13: 601-4.
Sajithlal G, Huttunen H, Rauvala H, Munch G (2002) Receptor for advanced glycation end products (RAGE) plays a more important role in cellular survival than neurite outgrowth during retinoic acidinduced differentiation of neuroblastoma cells. J Biol Chem 277: 6888-97
Wong A, Dukic-Stefanovic S, Gasic-Milenkovic J, Schinzel R, Wiesinger H, Riederer P, Munch G (2001) Anti-inflammatory antioxidants attenuate the expression of inducible nitric oxide synthase mediated by advanced glycation endproducts in murine microglia. Eur J Neurosci 14: 1-8
Loske C, Gerdemann A, Schepl W, Wycislo M, Schinzel R, Palm D, Riederer R, Munch G (2000) Transition metal mediated glycoxidation accelerates crosslinking of ß-amyloid peptide. Eur J Biochem 267:4171-4178.
Munch G, Schicktanz D, Behme A, Gerlach M, Palm D, Riederer P, Schinzel R (1999) Amino acid specificity of glycation and AGE-protein crosslinking reactivites determined with a dipeptide spot library. Nature Biotechnol 17: 1006 – 1010
Chair of Pharmacology School of Medicine University of Western Sydney Tel: ++ 61 (0)2 9852 4718
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