Derick Han, Ph.D.

Curriculum Vitae

Assistant Professor of Research 101 HMR, 2011 Zonal Ave
USC Research Center for Liver Diseases Los, Angeles, CA 90033
USC Keck School of Medicine (626) 643-0864, derickh@usc.edu

Education

  • University of California, Berkeley, BA – Sociology & Biochemistry 1987-1992
  • University of Southern California, PhD – Molecular Pharmacology & Toxicology 1997-2001

Research Experience

  • 1989-1993 Undergraduate researcher – Department of Molecular & Cell Biology at UC Berkeley – Dr. Lester Packer’s laboratory
  • 1993-1997 Staff research associate – Department of Molecular & Cell Biology at UC Berkeley
  • 1997-2001 Graduate student researcher – Department of Molecular Pharmacology & Toxicology at the USC School of Pharmacy
  • 2002-2006 Post-doctoral researcher – USC Research Center for Liver Diseases at the USC Keck School of Medicine
  • 2006-present Assistant professor of research – USC Research Center for Liver Diseases at the USC Keck School of Medicine

Teaching Experience

  • Tutor/Counselor – Consensus Head Injury Clinic – Berkeley, CA (1992-1995)
  • Teaching assistant – Physiology of Aging – upper division undergraduate course at the Department of Molecular Cell Biology at UC Berkeley (1993-1997)
  • Biochemistry and Biological Systems – pharmacy doctorate courses at the USC School of Pharmacy (1997-1999)
  • Lecturer/Instructor – Molecular Pharmacology and Toxicology and Mechanisms of Cell Signaling graduate courses at the USC School of Pharmacy (2004-present)
  • Biochemical and Molecular Sites of Drug Action – pharmacy doctorate course at the USC School of Pharmacy (2004-present)

Societies and Journals

  • Chemico-Biological Interactions – Editorial Board Member (2006 – present)
  • Oxygen Club of California – Secretary General (2004 – present)
  • Society for Free Radical Biology and Medicine

Honors and Awards

  • 2 Young Investigator Awards – Annual meeting of the Oxygen Society (in 1996 and 2000)
  • Presidential Fellow – USC Leadership Institute (2000)
  • Rho Chi Society – Pharmaceutical Honor Society (2001)
  • Pilot project research award – USC Research Center for Liver Research – (2004-2005)
  • Wright Foundation Research Grant – Wright Foundation (July 2006-July 2008)Zumberge Research and Innovation Award – USC
  • Provost for Research Advancement (July 2008 -)

Publications

Research Publications

  1. Kaplowitz N, Shinohara M, Liu ZX, and D Han. How to protect against acetaminophen: don’t ask for JUNK. Gastroenterology (in press).
  2. Saberi B, Hanawa N, Shinohara M, Gaarde W, Kaplowitz, N, and D Han. Regulation of H2O2-induced necrosis byProtein Kinase C and AMP-activated kinase signaling in primary cultured hepatocytes. American Journal ofPhysiology: Cell Physiology (2008) 295: C50-63.
  3. Hanawa N, Shinohara M, Saberi B, Gaarde W, D Han, and N Kaplowitz. Role of JNK translocation to mitochondrialeading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury. Journal of BiologicalChemistry (2008) 283: 13565-77.
  4. Zhou Q, Lam PY, Han D, and E Cadenas. c-Jun N-terminal kinase (JNK) regulates mitochondrial bioenergetics bymodulating pyruvate dehydrogenase activity in primary cortical neurons. Journal of Neurochemistry (2008) 104: 325-335.
  5. Inarrea P, Moini H, Han D, Rettori D, Aguilo I, Alava MA, Iturralde M, and E Cadenas. Mitochondrial respiratorychain and thioredoxin reductase regulate intermembrane Cu,Zn-superoxide dismutase activity: implications formitochondrial energy metabolism and apoptosis. Biochemical Journal (2007) 405: 173-9.
  6. Han D, Hanawa N, Saberi B, and N Kaplowitz. Hydrogen peroxide and redox modulation sensitize to TNF-inducedapoptosis of primary mouse hepatocytes. Free Radical Biology and Medicine (2006) 41: 627-39.
  7. Liu ZX, Han D, Gunawan B, and N Kaplowitz. Neutrophil depletion protects against murine acetaminophenhepatotoxicity. Hepatology (2006) 43: 1220-30.
  8. Gunawan BK, Liu ZX, Han D, Hanawa N, Gaarde WA, and N Kaplowitz. C-Jun N-terminal kinase plays a major rolein murine acetaminophen hepatotoxicity. Gastroenterology (2006) 131: 165-78.
  9. Han D, Hanawa N, Saberi B, and N Kaplowitz. Role of glutathione redox status in liver injury. American Journal ofPhysiology (2006) 291: G1-7.
  10. Han D, Canali R, Garcia J, Aguilera R, Gallaher TK and E Cadenas. Sites and mechanisms of aconitase inactivationby peroxynitrite: modulation by citrate and glutathione. Biochemistry (2005) 44: 11986-96.
  11. Inarrea P, Moini H, Rettori D, Han D, Martinez J, Garcia I, Fernandez-vizarra E, Iturralde M, and E Cadenas. Redoxactivation of mitochondrial intermembrane space Cu,Zn-superoxide dismutase. Biochemical Journal (2005) 387:203-9.
  12. Remiao F, Rettori D, Han D, Carvalho F, Bastos ML, and E Cadenas. Leucoisoprenochrome-o-semiquinoneformation in freshly isoalted adult rat cardiomyocytes. Chemical Research in Toxicology (2005) 17: 1584-90.
  13. Han D, Matsumaru K, Rettori D, and N Kaplowitz. Usnic acid induced necrosis of cultured mouse hepatocytes:inhibition of mitochondrial function and oxidative stress. Biochemical Pharmacology (2004) 67: 439-457.
  14. Remiao F, Rettori D, Han D, Carvalho F, Bastos ML, and E Cadenas. Leucoisoprenochrome-o-semiquinoneformation in freshly isolated adult cardiomyocytes. Chemical Research Toxicology (2004) 17: 1584-90.
  15. Han D, Canali R, Rettori D, and N Kaplowitz. Effect of glutathione depletion on sites and topology of superoxide andhydrogen peroxide in mitochondria. Molecular Pharmacology (2003) 64: 1136-1144.
  16. Han D, Antunes F, Canali R, Rettori D, and E Cadenas. Voltage dependent anion channels control the release ofsuperoxide from mitochondria to the cytosol. Journal of Biological Chemistry (2003) 278: 5557-5563.
  17. Antunes F, Han D, and E Cadenas. Relative contribution of heart mitochondria glutathione peroxidase and catalaseto hydrogen peroxide detoxification in in vivo conditions. Free Radical Biology and Medicine (2002) 33: 1260-1267.
  18. Antunes F, Han D, Rettori D, and E Cadenas. Mitochondrial damage by nitric oxide is potentiated by dopamine inPC12 cells. Biochimica et Biophysica Acta (2002) 1556: 233-38.
  19. Han D, Antunes F, Daneri F, and E Cadenas. Mitochondrial superoxide anion production and release intointermembrane space. Methods in Enzymology (2002) 349: 271-80.
  20. Xie Z, Wei M, Morgan TE, Fabrizio P, Han D, Finch CE, and VD Longo. Peroxynitrite mediates neurotoxicity ofamyloid beta-peptide 1-42- and lipopolysaccharide-activated microglia. Journal of Neuroscience (2002) 22: 3484-92.
  21. Han D, Williams E, and E Cadenas. Respiratory chain-dependent generation of superoxide anion towards themitochondrial intermembrane space. Biochemical Journal (2001) 353: 411-416
  22. Kobayashi M, Han D, and L Packer. Antioxidant and herbal extracts protect HT-4 neuronal cells against glutamateinducedcytotoxicity. Free Radical Research (2000) 32: 115-24.
  23. Sokol RJ, McKim JM, Goff MC, Ruyle SZ, Devereaux MW, Han D, Packer L, and G Everson. Vitamin E reducesoxidant injury to mitochondria and the hepatotoxicity of taurochenodeoxycholic acid in the rat. Gastroenterology(1998) 114:164-74.
  24. Lopez-Torres M, Thiele JJ, Shindo Y, Han D, and L Packer. Topical application of a-tocopherol modulates theantioxidant network and diminishes ultraviolet-induced oxidative damage in murine skin. British Journal ofDermatology (1998) 138: 207-15
  25. Han D, Sen CK, Roy S, Kobayashi M, and L Packer. Protection against glutamate-induced cytotoxicty in C6 glialcells by thiol antioxidants. American Journal of Physiology (1997) 273:R1771-78
  26. Han D, Handelman GJ, Marcocci L, Sen CK, Roy S, Kobuchi H, Tritschler HJ, Flohe L, and L Packer. Lipoic acidincreases de novo synthesis of cellular glutathione by improving cystine utilization. Biofactors (1997) 6:321-38.
  27. Reznick AZ, Han D, and L Packer. Cigarette smoke induced oxidation of human plasma proteins, lipids, andantioxidants; selective protection by the biothiols dihydrolipoic acid and glutathione. Redox Report (1997) 3: 169-174.
  28. Sen CK, Roy S, Han D, and L Packer. Regulation of Cellular Thiols in Human Lymphocytes by a-Lipoic Acid: A FlowCytometric Analysis. Free Radical Biology and Medicine (1997) 22: 1241-57.
  29. Haramaki N, Han D, Handelman GJ, Tritschler HJ, and L Packer. Cytosolic and mitochondrial systems for NADHandNADPH-dependent Reduction of alpha-lipoic acid. Free Radical Biology and Medicine (1996) 22: 535-42.
  30. Matsugo S, Yan LJ, Han D, Trischler HJ, and L Packer. Decomposition of alpha-lipoic acid derivatives byphotoirradiation-formation of dihydrolipoic acid from alpha-lipoic acid. Biochem Mol Biol Int (1996) 38:51-9.
  31. Han D, Handelman GJ, and L Packer. Analysis of reduced and oxidized lipoic acid in biological samples by highperformanceliquid chromatography. Methods in Enzymology (1995) 251:315-25.
  32. Han D, Tritschler HJ, and L Packer. Alpha-lipoic acid increases intracellular glutathione in a human T-lymphocyteJurkat cell line. Biochemical and Biophysical Research Communications (1995) 207:258-64.
  33. Constantinescu A, Pick U, Handelman GJ, Haramaki N, Han D, Podda M, Tritschler HJ, and L Packer. Reductionand transport of lipoic acid by human erythrocytes. Biochemical Pharmacology (1995) 50:253-61.
  34. Matsugo S, Yan LJ, Han D, Trischler HJ, and L Packer. Elucidation of antioxidant activity of alpha-lipoic acid towardhydroxyl radical. Biochemical and Biophysical Research Communications (1995) 208:161-7.
  35. Matsugo S, Yan LJ, Han D, and L Packer. Induction of protein oxidation in human low density lipoprotein by thephotosensitive organic hydroperoxide, N,N’-bis(2-hydroxyperoxy-2-methoxyethyl)-1,4,5,8-naphthalene-tetracarboxylic-dimide. Biochemical and Biophysical Research Communications (1995) 206:138-45.
  36. Matsugo S, Yan LJ, Han D, Trischler HJ, and L Packer. Elucidation of antioxidant activity of dihydrolipoic acid towardhydroxyl radical using a novel hydroxyl radical generator NP-III. Biochem Mol Biol Int (1995) 37:375-83.
  37. Shindo Y, Witt E, Han D, Epstein W, and L Packer. Enzymatic and non-enzymatic antioxidants in epidermis anddermis of human skin. Journal of Investigative Dermatology (1994) 102:122-4.
  38. Shindo Y, Witt E, Han D, Tzeng B, Aziz T, Nguyen L, and L Packer. Recovery of antioxidants and reduction in lipidhydroperoxides in murine epidermis and dermis after acute ultraviolet radiation exposure. Photodermatology,Photoimmunology and Photomedicine (1994) 10:183-91.
  39. Shindo Y, Witt E, Han D, and L Packer. Dose-response effects of acute ultraviolet irradiation on antioxidants andmolecular markers of oxidation in murine epidermis and dermis. Journal of Investigative Dermatology (1994)102:470-5.
  40. Handelman GJ, Han D, Tritschler H, and L Packer. Alpha-lipoic acid reduction by mammalian cells to the dithiolform, and release into the culture medium. Biochemical Pharmacology (1994) 47:1725-30.
  41. Constantinescu A, Han D, and L Packer. Vitamin E recycling in human erythrocyte membranes. Journal of BiologicalChemistry (1993) 268:10906-13.
  42. Serbinova E, Kagan V, Han D, and L Packer. Free radical recycling and intramembrane mobility in the antioxidantproperties of alpha-tocopherol and alpha-tocotrienol. Free Radical Biology and Medicine (1991) 10:263-75.

Book Chapters

  1. Yap LP, Chang AHK, Han D, and E Cadenas. Free radical biology, mitochondrial functions, and nitric oxide. In Free Radicals in Ophthalmic Disorders. Zierhut M, Cadenas E, and NA Rao ed., Informa healthcare: New York (2008) 1-10.
  2. Han D, Hamilton R, Lam PY, and L Packer. Modulation of cellular redox and metabolic status by lipoic acid. In Alpha Lipoic Acid: Energy Production, Antioxidant Activity and Health Effects. Patel M., and L. Packer eds., Taylor and Francis Group: Boca Ranton(year 2008) 293-314.
  3. Yap, LP, Han D, and E Cadenas. Mitochondrial generation of reactive oxygen and nitrogen species and redox signaling. In Search on Glaucoma. C Erb ed., Publiziert von Excerpta Medica: Amsterdam (2007) 4-15.
  4. Han D, Kobayashi M, Cadenas E, and L Packer. Oxidative stress in glutamate neurotoxicity. In Free Radicals in Brain Pathophysiology. Poli G., Cadenas, E., and L. Packer eds., Marcel Dekker: New York(year 2000) 127-51.
  5. Han D, Loukianoff S, and L McLaughlin. Oxidative stress indices: analytical aspects and significance. In Handbook of Oxidants and Antioxidants in Exercise. Sen C.K., Packer, L., and O. Hanninen eds., Elsevier: New York(year 2000) 433-84.
  6. Serbinova E, Kagan V, Han D, and L Packer. d-Alpha-tocotrienol is a more powerful membrane antioxidant than d-Alpha-tocopherol. In Oxidative Damage & Repair: Chemical, Biological, and Medical Aspects. K.J.A. Davies ed., Pergamon Press: New York(year 1991) 77-81