Anthony Smith Ph.D.

Anthony’s work is having a significant impact in the research community by helping to elucidate the role of R-lipoic acid in maintaining human health and reducing the loss of function associated with age-related disease. Anthony is a leading international authority on aging, lipoic acid and vascular disease. Anthony earned his Ph.D. and did his post-doctoral work at the Linus Pauling Institute studying the molecular mechanisms of cardiovascular aging and the therapeutic potential of R-lipoic acid. Anthony is a private contractor, consultant and technical advisor to the nutraceutical industry. He oversees the GeroNova quality control and assurance (QC/QA) programs and has trained the GeroNova lab technicians in QA/QC methods and Good Laboratory Practices (GLP). Dr. Smith is a member of Sigma Xi, the Biochemical Society and the American Heart Association.

Publications & Writings in Process:

  1. Smith AR, Visioli F, Frei B, Hagen TM. Lipoic acid significantly restores, in rats, the age-related decline in vasomotion. Br J Pharmacol. 2008 Apr;153(8):1615-22.
  2. Carlson DA, Smith AR, Fischer SJ, Young KL, Packer L; The Plasma Pharmacokinetics of R-(+)- Lipoic Acid Administered as Sodium R-(+)-Lipoate to Healthy Human Subjects (2007) Alt Med Rev 12(4) 343-351.
  3. Smith, AR, Visioli F, Frei B, Hagen TM. Age-related changes in endothelial nitric oxide synthase phosphorylation and nitric oxide dependent vasodilation: evidence for a novel mechanism involving sphingomyelinase and ceramide-activated phosphatase 2A. Aging Cell 5, 391-400 (2006).
  4. Smith AR, Visioli F, Hagen TM. Plasma membrane-associated endothelial nitric oxide synthase and activity in aging rat aortic vascular endothelia markedly decline with age. Arch Biochem Biophys 454, 100-5 (2006).
  5. Smith AR; Elevated ceramide levels contribute to the age-associated decline in vascular endothelial nitric oxide. Pharmacological administration of (R)-lipoic acid partially restores function. Ph.D. Thesis. Oregon State University. (2005).
  6. Smith AR, Shenvi SV, Widlansky M, Suh JH & Hagen TM. Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress. Curr Med Chem 11, 1135-46 (2004).
  7. Smith, A.R. & Hagen, T.M. Vascular endothelial dysfunction in aging: loss of Akt-dependent endothelial nitric oxide synthase phosphorylation and partial restoration by (R)-alpha-lipoic acid. Biochem Soc Trans 31, 1447-9 (2003).
  8. Smith AR, Visioli, F & Hagen TM. Vitamin C matters: increased oxidative stress in cultured human aortic endothelial cells without supplemental ascorbic acid. FASEB J 16, 1102-4 (2002).
  9. Carlson DA, Smith AR, Ulrich H. The case against controlled release lipoic acid: a pharmacokinetic-mechanistic based argument. http://www.geronova.com/docs/controlled_release_lipoicacid.pdf