Research Overview

GeroNova Research is setting the industry standards for research, analysis and lipoic acid products.

GeroNova Publications

Contrasting effects of lipoic acid and lipoamide on mitochondrial biogenesis and mitochondrial function: implications for diabetes prevention and aging: a hypothesis paper. Journal of Bioscience and Medicine 2012, 1:5 (in press) Shen W.⁽¹⁾ Carlson DA.⁽²⁾ Cadenas E.⁽³⁾ Packer L.^(3,4) and Liu J.^(3,4)

Author Affiliations:

1. State Key Laboratory of Medical Genomics,Shanghai Key Laboratory of Vascular Biology and Department of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.

2. GeroNova Research, Inc., Richmond, CA 94804, USA.

3. Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA.

4. Center for Mitochondrial Biology and Medicine, School of Life Science & Technology and Frontier Institute of Life Science, FIST, Xi’an Jiaotong University, Xi’an 710049, China.

Evaluation of the Role of Chirality and Amide Substitution in Redox Modulation of Signal Transduction by Lipoic Acid and Derivatives. Poster Presentation, Oxygen Club of California, Alba, Italy June 20-23, 2012. Carlson DA.⁽¹⁾ He DY.⁽¹⁾ Kalashnikova E.⁽¹⁾ Gendelman R.^{(1, 2)} Fischer SJ.⁽¹⁾, Packer L.⁽³⁾

Author Affiliations:

1.GeroNova Research Inc, 4677 Meade Street Richmond CA. 94804

2. University of California San Francisco Cancer Center, San Francisco, CA 94115

3. Pharmacy and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90089

Redox Modulation of Cell Signaling by Lipoic Acid & Derivatives. Power Point presentation, June 21, 2012 (15:30) Oxygen Club of California, Alba, Italy June 20-23, 2012. Carlson DA.

Therapeutic Potential of Lipoamide and Enhanced Mitochondrial Biogenesis for Treatment of Insulin Resistance. Shen W, Carlson DA, Packer L, Cadenas E, Liu J. Chapter 5 in Mitochondrial Signaling in Health and  Disease (93-111) Eds. Orrenius S, Cadenas E and Packer L. CRC Press, Taylor & Francis Group, Boca Raton, London, New York (2012)

The Thioctic Acid/Lipoic Acid Legacy Archive Project 2010

David A. Carlson & Sarah J. Fischer

Introduction
List of Abstracts, Titles & Full Text Articles
Early Japanese ads for Thioctic acid

Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease.

Maczurek A (b,c), Hager K (a), Kenlies M (a), Sharman M (d), Martins R (a), Engel J (e), Carlson DA (f), Münch G (b,c). Advanced Drug Delivery Reviews (2008).
Read the abstract on the Pub Med website.

Affiliations

A validated, normal phase HPLC method for the analysis of lipoic acid enantiomers. Carlson DA & Smith AR. June 6, 2008.

The validated method here may be used by any individual, academic institution, or analytical laboratory as long as credit is given to the authors & GeroNova Research Inc. as the source of the method. We are offering this method to the industry in order to educate testing laboratories in the analysis of R-Lipoic Acid containing products.To date, this is the fastest and most reproducible method available for the analysis of the enantiomers of lipoic acid.
Download the method here.

An Evaluation of the Stability and Pharmacokinetics of R-lipoic Acid and R-Dihydrolipoic Acid Dosage Forms in Plasma from Healthy Human Subjects

Carlson DA, Young KL, Fischer SJ, Ulrich H. Chapter 10 in: Packer L, Patel M, eds. Lipoic Acid: Energy Production, Antioxidant Activity and Health Effects. London, England: Taylor & Francis Publishers; 2008:235-270.

Outline of Chapter 10

Buy the (hardcover) book at our online store.

The Plasma Pharmacokinetics of R-(+)-Lipoic Acid Administered as Sodium R-(+)-Lipoate to Healthy Human Subjects.

Carlson DA, Smith AR, Fischer SJ, Young KL, Packer L. Altern Med Rev 2007;12(4) 343-351

Download the pdf

Download the pdf in Japanese - Translation by Akihito Urano.
View the poster

This paper has been cited in the following articles; View pdf

A comparison of the pharmacokinetic profiles of lipoate enantiomers with the racemic mixture in healthy human subjects indicates possible stereoselective gut transport.

Carlson DA, Smith AR, Fischer SJ, Young KL.
View the poster from OCC Santa Barbara, CA March 12-15, 2008

Further characterization of the lipoic acid enantiomers provide new research opportunities. Stereochemistry, Pharmacokinetics & Metabolism:Toward a Comprehensive Mechanism of Action.

Oxygen Club of California PowerPoint presentation by David A.Carlson, March,15, 2008.
Download the PowerPoint presentation
Download the references

Lipoic acid in Alzheimer's disease - From basic therapeutic concepts to clinical trials.

Marlies Kenklies, Klaus Hager, Gerald Münch, Shanmugam Kirubakaran, Annette Maczurek, Grant Stuchbury, David Carlson
Download the abstract from the OCC conference, March 2008

The case against controlled release lipoic acid: A pharmacokinetic-mechanistic argument (part 1)

Read the paper
David A Carlson; CV
Anthony R Smith, Ph.D; CV
Heinz Ulrich, M.D.; CV

A chronological listing of Lipoic Acid conferences.

View list

Contact us if you know of other Lipoic Acid conferences not listed.